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The Villages
Monday, November 21, 2022

Should men take testosterone?

Dr. Gabe Mirkin

Many men take testosterone because they think it will help them to function better sexually, increase muscle strength, raise bone density, and improve mood, behavior, and mental function. As of May 2022, the only FDA-approved indication for men to take testosterone is having low testosterone levels. Testosterone has not been approved for age-related drops in testosterone, and there is significant concern that testosterone use is associated with increased plaques in the arteries leading to the heart (Circulation, March 5, 2019;139(10)), which would increase risk for heart attacks (JAMA, 2017;317(7):708-716).

A study of 172,000 men found that those who have the genes for high blood levels of testosterone are at a 37 percent increased risk for suffering a heart attack, eight times the risk for heart failure and double the risk for blood clots in the brain and lungs (Brit Med J. March 6, 2019). Many other studies show that weight lifters and other men who take large doses of testosterone (when their own testosterone levels are normal) are at increased risk for suffering heart attacks (Cureus, Jul 22, 2020;12(7):e9333). Recreational weight lifters who take anabolic steroids and other hormones that mimic testosterone can suffer from significant heart damage (left ventricles) even many years after they stop taking these drugs (Circulation, May 23, 2017).

Testosterone may also increase risk for sleep apnea, acne, stimulating noncancerous growth of the prostate or of an existing prostate cancer, increasing red blood cell production to increase clotting risk, high blood pressure, or swelling of the legs (Ther Clin Risk Manag, June 22, 2009; 5: 427-448).

Approved Uses of Testosterone
The U.S. Food and Drug Administration requires testosterone labels to list the increased risk of heart attack and stroke, and the Endocrine Society recommends that testosterone be given only to men who:
• have proven low levels of testosterone,
• have not had a heart attack or stroke in the last six months, and
• are at very low risk for prostate cancer (The Journal of Clinical Endocrinology and Metabolism, March 2017).
In spite of these very real concerns, global sales of testosterone have increased 12-fold in the last 20 years.

Testosterone Gel Did Not Improve Memory
In the Testosterone Trials from the University of Pennsylvania(TTrials), 788 men over 65 years of age who had low levels of testosterone were given either testosterone gel or placebo for one year. In 493 of these men who had age-associated memory impairment, the treatment with testosterone was not associated with improved memory or other cognitive functions such as verbal memory, visual memory, executive function, or spatial ability (JAMA, 2017;317(7):717-727).

My Recommendations
• Men with normal blood levels of testosterone should not take testosterone as it can increase risk for heart attacks, clots, and liver and lung damage. It can also shut down their own natural production of testosterone to make them sterile.
• Older men should not take testosterone unless their testosterone is very low (at least below 150 ng/dL), meaning that their brain hormones or testicles are damaged so they cannot make adequate amounts of testosterone.
• Most older men who suffer from poor sexual function have conditions that cause the damage, such as excess weight, diabetes, arteriosclerosis or other life-shortening conditions. Testosterone is not a solution for these conditions. These men can often correct their sexual dysfunction and prolong their lives by changing the lifestyle habits that caused their problems.

• Almost never should men take testosterone pills because they can damage the liver. If they do choose to take testosterone, the form of choice is a gel that is rubbed on and absorbed through the skin, so it is not absorbed from the intestines and passed immediately to the liver.

Dr. Gabe Mirkin is a Villager. Learn more at www.drmirkin.com

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